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Twain Harte Pharmacy


18711 Tiffeni Suite #45

Twain Harte, CA



Pharmacy: 209-586-3225

Variety: 209-586-3789

Fax: 209-586-3249

Pharmacy Hours

Monday-Friday: 9a.m.-5:30p.m. *Closed 1p.m.-1:30p.m.

Saturday: 10a.m.-2p.m.

Sunday: Closed

Variety Hours

Monday-Thursday: 9a.m.-6p.m.

Friday-Saturday 9a.m.-7p.m.

Sunday: 9a.m.-5p.m.


A good neighbor is someone who cares about your community, your family, and your well being. That’s Twain Harte Pharmacyyour local Health Mart Pharmacy. Twain Harte Pharmacy has been part of the local community since 1983, serving the residents of and the surrounding area. We’re able to offer quality products and services – at prices that are competitive with the big national chains. Plus, we offer a special dose of caring that makes you feel right at home. Get to know us, and get to know the value we can bring to your family’s life.


Michael Clark, Pharmacist in Charge

Long time Tuolumne County pharmacist, friendly, helpful and knowledgeable.

Erin, Pharmacy Catalyst

Hardworking, honest, efficient, fast and dependable.

Toni, Pharmacy Technician

Knowledgeable, fast and efficient billing specialist that goes above and beyond.

Mickey, Pharmacy Technician

Reliable, honest and hard-working.

Jennifer, Pharmacy Technician

Honest, nice and willing to take on anything.

Martha, Pharmacy Clerk

Considerate and provides reliable and friendly service.

Abby, Pharmacy Clerk

Happy, energetic and eager to help everyone.

Justice, Pharmacy Clerk

Open, analytical and ready for any situation.

Medication Services

  • Medication Adherence
  • Delivery
  • Durable Medical Equipment
  • Long Term Care Services
  • Consumer Drug Take Back
  • Immunizations
  • Multi-Dose Packaging

Over The Counter

  • Pain Medication
  • Cold and Allergy Medication
  • Vitamins and Supplements
  • Oral Health Products
  • First Aid Items
  • Infant Care
  • Hair Care
  • Shower and Bath Items
  • Sunscreen and Bug Spray

Medication Adherence

An estimated 50 percent or more of medications for chronic conditions, such as high cholesterol and diabetes, are not taken as prescribed.

Medication non-adherence can lead to worsening health conditions, hospitalizations and death. Whatever the reason is for medication non-adherence, we have a solution for you. Ask one of our team members how we can help you today.

Durable Medical Equipment (DME)

Our pharmacy offers a variety of medical equipment and supplies.

Our medical equipment may include, but is not limited to:

  • Equipment to assist walking such as canes and walkers
  • Bathroom equipment such as benches
  • Orthopedic supplies such as back support belts and compression stockings
  • Nebulizers

Reviews – Twain Harte Pharmacy


  • Jessica T.
    San Francisco, CA


    Updated review

    Thank you.

    Thank you for existing.

    Thank you for showing up everyday with character and a smile.

    Twain Harte Pharmacy makes me so happy.

    From comfortable sweats, to socks, to dishwashing detergent, to essential oils, to playing cards, to games, to fabrics, to sewing equipment, to tye-dye shirts and sooooooo much more – this place is pure magic.

  • Megan T.
    Santa Rosa, CA

    Great store that seems to have a little bit of everything! Second time here for fabric, what an amazing selection and the prices are great! Besides buying 20 yards of fabric I got a few items of clothing & some gifty things. Good prices and great selection on everything I looked at.
    Shout out to Diana who was working the front end and who is a great asset to this store. I bought some cheap ’emergency back-up’ sunglasses at the store since mine where missing and I needed to see for the drive down the hill. Diana asked me if I would be wearing the glasses out, and I said yet. Not only did she take off the price tag and stickers on the lens…she handed them to me wrapped in a tissue to avoid fingerprints and to clean up the lenses. She was very friendly & knowledgeable.
    This store is a must stop if you are in the area, from gifts to gear, they have it all

  • Tim And Gina B.
    Escalon, CA

    HORRIBLE PHARMACY – GO TO SONORA. They literally will not fill your prescription until you show up to pick it up. Then they say 10-15 minutes, which quickly turns into hours. My dad warned me not to use them because he has ALWAYS had problems getting my moms meds. It sometimes took days and many return trips to get them to fill a simple RX. If I could give no stars I would. Save yourself a lot of inconvenience and just go to Rite Aid. This place should be shut down FFS.

  • Corrie B.
    Sonora, CA

    They have a wide variety of products, like a locally owned Walmart. Great sales staff. Full hallmark section. Huge craft supplies inventory!

  • Emma A.
    Sonora, CA

    AWFUL. AWFUL. AWFUL.  Every single time you go to pick up your medications, they aren’t ready, or “they’re on hold for insurance reasons”. On hold every single month? It look my brother 2 months to get his life saving insulin, even though we received a letter in the mail from insurance saying it had been approved the whole time. If you call in 3 days in advance, they still won’t be ready and you won’t get a call telling you that. Avoid them if you actually enjoy getting your medications. I’m currently sitting here waiting for medication to be ready while listening to the pharmacist and another employee talk about me and other “rude customers”.

  • Ron C.
    Pleasanton, CA

    While Twain Harte is not my typical destination, I wandered around these parts for a winter retreat in the mountains.

    Twain Harte offers a bit of civilization in these parts and the Twain Harte Pharmacy is the “Superstore” around here.

    In addition to pharmaceuticals you can find practically everything you need!

    Interestingly enough, they have a door way that connects to the liquor store…and the grocery store is right next door to that.

    My wife loves this places (As does my mother-in-law).

  • Christina T.
    Truckee, CA

    I like to pretend I am going to back in time in this place. It reminds me of a general store from back in the day. They have sporting goods, clothes, shoes, medications…. I mean… you could get lost in there!

    So, I imagine that this place is what a Woolworth was like in 1930 with the variety of things here!

    We were able to get my daughter crocs because her snow boots were just SOAKED. We also found candy, snow toys, a jacket, tylenol, and if we were so incline… a whole section devoted to knick knacks from Christmas.

    Stop in and support this local business

  • Mark M.
    CA, CA

    Great pharmacy, in the woods so incredible that they have one here! They also have a neat shop for all of your household needs! I really like well organized, reasonably priced stores in small towns, next to a liquor store!! Lol.

  • Marc M.
    Sutter Creek, CA

    Now this is what a Thriving Hometown Small Town Retail is all about.  Why?

    1. The Buyer(s) for this store are freaking geniuses. (More on this; below)

    2. The Management has successfully maintained a modified version of a business model that basically bingo’d years ago with the Death of Woolworth and Birth of Wal-Mart. Many similar retailers attempted to fine tune that old dead business model and nearly all have failed. To know that Twain Harte Pharmacy didn’t fail – heck these folks thrive – is quite an accomplishment and one that deserves recognition.

    3. While there is an attached store where one can purchase the dark liquor, it’s nice that the purchase of Satan’s Syrup and related tawdry Clamper and Clamper-like enhancements are distinctly divided so as to maintain a polite distance between the day drinkers and those for whom are without challenges to maintaining a capacity of self-control. Or at least understand the decorum in which one waits until after the sun has taken its leave for the eve to retrieve ones TJ Swam Magic Moments and Mello Days. Or so it was mentioned by someone I met with an affinity for screw top fortified beverages.

    4. Unlike a retailer very close by and not named Drain Apart Markup, prices at this store are reasonable considering its location. It’s a good ways away from the distribution networks of basically all providers and many things likely come by small delivery vehicle or UPS. However, these folks don’t take that to the extreme or use it as justification to gouge a captive audience. I find that quite cool and it’s appreciated.

    Now If old Sam had his way, this store would have long since closed and y’all would be standing in a line 14 miles away with 14 screaming kids high on PopTarts, 7 cycling teen moms topping off the estrogen and progestogen and a dozen or so pre-AARP yet post-ED dudes redeeming coupons for blue pills they try to disguise by also buying Pez dispensers. (Its always the Smurf ones too. C’mon guys show some original go with Patrick Starfish….his house is Rock Solid.)  Fill your prescription here and you don’t have to deal with all that and know at the same time that your business supports the local community.

    Great self service photo kiosk for prints and enlargements etc. Easy to use and inexpensive.
    Quality compares to anything you’ll find in CVS or Rite Aid.

    Lastly, this store has some really cool and unique items for gifts, home decor and paper/card specialty store type of merchandise. Very much a step above the old Woolworth in that respect and light years better than and of finer quality than Walmart. What really stands out is their craft section…..-HOLY CRAFTS- it’s amazing.  If you are visiting with one of those ETSY or Pintrest chicks and she’s getting annoying because she forgot her cricket machine, bring her HERE. There are beads, baubles, hoopachews, foil, fabrics and related stuff to glue stick or otherwise affix to anything that needs a bird on it.

    Genius. Great store. Wish I had thought of it first.

    I would have put a bird on it.

  • Randy M.
    Mi-Wuk Village, CA

    A very handy and convenient store up here in the mountains.  Staff is courteous and they have an excellent card selection, with Leaning Tree cards as a staple.

  • Andrea W.
    La Habra, CA

    It’s like a craft store, clothing store, home goods store, toy store and pharmacy all in one place. Kind of crazy how crowded it all is, but they have a really great supply of quilting and jewelry making supplies. Prices are a little on the high side. It is neatly organized and the staff are friendly. They have great sidewalk sales. Everytime we are in Twain Harte we visit.

  • Deolinda R.
    Hanford, CA

    I love this place, it is like a five and dime store, brings back childhood memories of shopping while on vacation in a remote place. I love the fabric selection.

  • Jacqueline W.
    Sacramento, CA

    This store is amazing. It’s a for real five and dime store in the middle of the forest. In other words, you can get anything you need here: snacks and drinks (alcoholic and non), clothes (from camper chic essentials to work wear to swimsuits, and a large selection of accessories),  high end gift shop gifts (e.g. aprons, wine stoppers, fancy bakeware, cupcake decorating tools, gourmet cookbooks, and quality wineglasses), and craft supplies for all your sewing project and scrapbooking needs. This place has magazines, CDs, first aid supplies, and greeting cards.

    If you are up here on a trip and you forgot something: it’s here.

  • Carol S.
    Castro Valley, CA

    I want to give this place a shout out. I went on vacation up in the Sierras over July 4th weekend and, in a phenomenal brain cramp, left my prescription med at home. I didn’t realize this until around 8 PM on July 4. Nothing to be done but spend a bad night berating myself for being so stupid! Next morning I called doctor as soon as they opened. They told me they frequently get calls from frantic people who go on vacation without prescriptions. I was afraid Twain Harte Pharmacy, being in such a small town, would not be able to fill my prescription in which case I’d have to go to CVS in Sonora, about 50 mile round trip. My doctor’s office said Twain Harte Pharmacy is on national data base and sent a fax. I waited an hour, as the pharmacy was not yet open, then called. They said they would have my prescription ready for me in 20 minutes – and did. I was clearly just passing through, not a local, not someone who might become a regular customer, but they literally saved the day for me. So thank you.

  • Staci B.
    Napa, CA

    What a GEM!! If I could give 10 stars, I would! This place has something for everyone. We thought it would be your run of the mill pharmacy with a few trinkets. Not so!! It has crafts, gifts, clothes (although most are pretty spendy) toiletries, toys, electronics, decorator items & even a fabric department!!

    This is a must stop for our family!!

  • Julie B.
    Twain Harte, CA

    I live in Twain Harte and any time I need a nice card, a gift (they wrap in beautifully for free with a minimum purchase) or just about anything I need I can find it here. They have just about any kitchen utensil you can think of, their craft department is awesome, it has great brushes, canvas and oil paints, along with anything else you can think of. I love this store. I do agree with some of the other reviewers that the manager(?) is quite stand-offish, but the rest of staff is very nice.

  • California T.
    Modesto, CA

    If you can’t find something to buy in this fabulous drugstore, you need to have your eyes examined!

    In addition to the “cute aisle” which is near the middle of the store, there is also the gift area in the front plus the best selection of clothing you will find in the area. For those who are sewers and quilters there is the best ever selection of fabric at fabulous prices.  Probably no one would Tavel this far up the hill for fabric but if you saw the selection you would.

    Practical stuff?  Oh well, they have,that too….and tons of it plus a wonderful personal pharmacy.

    I love browsing this store….just delightful.  I have been coming here for about  40 years and I’ve never been disappointed.

  • Julie B.
    Brentwood, CA

    Love, love this place. Great prices for fabric, a nice variety of clothing, all kinds of gifts and my favorite brand of earrings, Silver Forest. A must stop every time I’m near.

  • Carol M.
    Truckee, CA

    Comic books, arts and crafts, lake floats, to cp shades clothes. This is the best store ever!

  • Anne S.
    Merced, CA

    I am old hippie and a quilter, we live in MiWuk, this is the MOST delightful store I have ever been in. Need it? They have it. Ok, they did not have the right size curtain rod, but that was a first.  I know women who travel across California for their fabrics, not to mention their yarn, or dollhouse crafts, or, or, or. And this is all on top of normal drugstore supplies. I buy most of my clothes here, too.

    An after thought. An unfortunate after thought. The manager is the most unpleasant, unhappy, un-cooperative fellow I have ever had the disadvantage of running into. When he was asked about a major defect in a piece of clothing he just shrugged. Buy it or don’t.

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