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How Long Does Trazodone Last :

We’ve all been there:

We were exhausted out of our minds, but we couldn’t sleep.

Insomnia can tax our body, sap our vitality, and drain what little mental capacity we have left. This is especially true when, despite experimenting with sleep hygiene and over-the-counter sleep aids, we remain wide awake.

Trazodone is a prescription drug that is frequently prescribed by doctors in situations such as these – when our sleepiness persists despite all you’ve tried.

Trazodone is an antidepressant that is most commonly used to reduce symptoms of anxiety and depression. Its soothing side effects have made it a beneficial sleep option for many. Furthermore, unlike some other sleep medications, such as Ambien, Trazodone has a low risk of dependency and is not classified as a prohibited narcotic.

We’ll go through what to expect if your doctor gives you a Trazodone prescription, including how long the medication lasts.

How Long Does Trazodone Last

The short answer :

Trazodone should be taken right before bedtime to treat insomnia. When taken at the recommended dosage, it will help you sleep for a full 7-9 hours.

After weeks or even months of sleep deprivation, this sounds pretty dreamy.

One thing to keep in mind is that you should only take your prescription right before bed if you don’t have any other obligations for the night. Trazodone has been shown to be fast-acting for many people, so make sure you’re finished with your day and ready for bed.

After taking Trazodone, you should avoid driving or engaging in any other activities that require concentration.

How Long Does Trazodone Take To Leave Your System? 

Trazodone, marketed under the brand name Desyrel, is an antidepressant. It is a serotonin antagonist and reuptake inhibitor (SARI). The Federal Drug Administration (FDA) has approved the medicine for the treatment of major depression and anxiety disorders. It is also used to treat sleep disturbances.

You may be wondering how long Trazodone lingers in your system if you take it. It could be for a variety of causes. You might not want an antidepressant to show up on a pre-employment drug test, for example.

Trazodone, like many antidepressants, can have certain unpleasant side effects. Stopping or adjusting your dosage can result in unpleasant withdrawal symptoms.

So, how long will Trazodone be in your system? It all depends.

Trazodone has a half-life of 5 to 13 hours. This indicates that the drug will most likely remain in your system for up to 40 hours after you’ve taken it.

It is vital to note that the prescription’s effects will not necessarily continue that long.

Because most doctors give Trazodone at a low dose to help with sleep, the medication’s sleep aid effects normally wear out after the first half-life.

Some people, however, report feeling foggy the next morning. As a result, it is critical that you do not drive or do anything else that requires you to be attentive the next morning. In some instances, you may perceive yourself to be more alert than you actually are. As a result, it’s critical to take a few extra measures until you know how the drug affects you and for how long.

To help you adapt, most doctors will advise you to take your first few doses on days when you don’t need to drive anywhere or have any commitments to be anyplace first thing in the morning.

If you wake up sluggish or the effects continue too long after trying Trazodone for a few days, your doctor may decide to reduce your prescribed dosage or try another sleep therapy entirely.

Because Trazodone is a prescription medicine, you should always get the advice of a doctor before using it to help you sleep. Once you’ve been given a prescription, make sure to follow your doctor’s instructions.

What exactly is trazodone?

Trazodone is an antidepressant medicine that has been licensed by the Food and Drug Administration (FDA).

This medication affects your body in a variety of ways. One of its functions is to regulate the neurotransmitter serotonin, which aids brain cell communication and regulates a variety of processes such as sleep, thinking, mood, hunger, and behavior.

What exactly is trazodone

Even at modest doses, trazodone can make you feel drowsy, weary, and relaxed. This is accomplished by inhibiting brain chemicals that interact with serotonin and other neurotransmitters, such as 5-HT2A, alpha1 adrenergic receptors, and H1 histamine receptors.

One of the main reasons trazodone works as a sleep aid is because of this impact.

FDA WARNING ABOUT TRAZODONELike many antidepressants, trazodone has been issued a “Black Box Warning” by the FDA.

Taking trazodone has increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients. People taking this medication should be closely monitored for worsening symptoms and emergence of suicidal thoughts and behaviors. Trazodone is not approved for use in pediatric patients.

What Exactly Is Insomnia? 

Insomnia can take various forms, and the term is used to describe a wide variety of sleep issues, from difficulties falling asleep to waking up in the middle of the night and being unable to sleep again.

Insomnia is classified into two types: primary and secondary.

What Exactly Is Insomnia

Primary insomnia is characterized by sleep issues that are not caused by other physical or psychological illnesses.
Secondary insomnia is defined as sleeping difficulties induced by a physical ailment or a mental health disorder.

The treatment of primary insomnia entails addressing and tackling the underlying sleep disturbance.

Secondary insomnia requires treatment of the underlying disease as well as pharmacological or behavioral treatment of the insomnia itself.

Insomnia can be classified into several subtypes.

Acute insomnia: Typically brought on by a stressful life event, acute insomnia is a brief, fleeting bout of sleep disruption that generally resolves without the need for medication.
Chronic insomnia: Insomnia is considered chronic if you have difficulty sleeping or staying asleep at least three evenings per week for three months or more. There are numerous causes, and treatment differs accordingly.
Comorbid insomnia: When insomnia occurs in conjunction with another condition, it is referred to as comorbid insomnia. Anxiety and depression are common causes of sleeping disorders. Sleeping might be difficult if you have debilitating back pain or if you have a condition like arthritis.
Late insomnia is defined as waking up excessively early in the morning and being unable to fall back asleep.
Maintenance insomnia is defined as an inability to sleep and is characterized by waking up during the night and finding it difficult to get back asleep.
Sleep onset insomnia: If you have trouble falling asleep when you get into bed, you have onset insomnia.

Many drugs, including Ambien and trazodone, are used to treat the symptoms of insomnia.

How to Sleep with a New Tattoo

Dosage for Sleep

Trazodone pills are available in a variety of doses for sleep:

50mg \s100mg \s150mg \s300mg
When taken as a sleep aid, start with 25 to 50mg and gradually up to 100mg if necessary. Trazodone has also been proven in studies to be useful at lower doses.

Dosage for Sleep

As you can see, trazodone works effectively for treating insomnia and does not require high doses of this non-addictive medication.

But what about the disadvantages of trazodone for sleep?

We’ll now look at the potential adverse effects of trazodone if it’s given for sleeplessness.

Trazodone is most commonly given as a sleep aid in doses ranging from 25mg to 100mg.

However, studies have shown that lower doses of trazodone are beneficial and may induce less daytime sleepiness and fewer adverse effects due to the drug’s short duration of action.

Factors Influencing the Duration of Trazodone Absorption 

Trazodone has a half-life of five to nine hours. This indicates that it will take your body approximately seven hours to clear half of the medicine.

A single dose of Trazodone can last in the body for one to three days in a healthy adult.

However, this is not the case for everyone. Many factors determine how long this medicine can remain in your system, including:

Dosage: The longer Trazodone metabolites remain in your system, the larger the dose. Smaller amounts are often excreted more quickly than higher doses.
Age: According to certain research, the half-life of Trazodone is longer in older persons.
Weight: Body mass and fat can influence how quickly the medicine metabolizes and how long it stays in fat cells.
Frequency of use: If you use the drug on a regular basis, it will take longer to leave your system.
The most recent time taken: Certain tests can only identify it after a few hours or days of use. Others are able to identify it after three months.
Genetics and metabolism have an impact on liver function as well as the enzymes that metabolize Trazodone.
The sort of drug test is another factor to consider. Continue reading to find out how long the medicine can be found in your urine, hair, blood, and saliva.

Is it legal to use as a sleep aid? 

Though the FDA has licensed trazodone for use as a treatment for depression in adults, it has also been given as a sleep aid for many years.

Clinical trials are used by the FDA to approve drugs for certain illnesses. Off-label prescribing occurs when doctors prescribe a medication for a condition that is not approved by the FDA.

Off-label usage of a drug is a common occurrence. Approximately 20% of drugs are prescribed off-label. Off-label medication can be prescribed by doctors based on their experience and judgment.

How Long Does Trazodone Remain in Urine? 

The most common method of drug screening is urine testing. Antidepressants are not commonly regarded as addictive medications. Most drug tests do not look for them.

However, certain antidepressants might cause cross-reactions that result in false-positive drug test results. Trazodone is one of these drugs.

Trazodone, the parent drug, can be eliminated by your body in roughly two days. Trazodone, on the other hand, degrades into metabolites after ingestion. These persist in your body for a considerably longer period of time.

Trazodone metabolites can cause false-positive amphetamine urine test results for up to 26 days.

How Long Does Trazodone Last in Hair? 

Trazodone metabolites are accumulated in rapidly developing cells such as hair.

Drugs, including antidepressants, can be detected in hair for a prolonged period of time. Trazodone metabolites can be detected in hair for at least 90 days.

How Long Does Trazodone Remain in Your System? 

Blood tests can detect Trazodone compounds up to three days after the last time they were taken.

How Long Does Trazodone Remain in Saliva? 

Drugs can be detected in saliva testing within a few hours of intake. This indicates that Trazodone can be detected faster using a saliva test than it can with a urine test.

Trazodone metabolites can be detected in saliva tests for a longer period of time than in blood testing. Saliva testing can identify these compounds up to four days after the last time they were tested.

How Long Does Trazodone Remain in Laboratory Tests? 

Trazodone and other antidepressants, yet again, are uncommon in routine drug testing. However, laboratories can test for Trazodone.

The length of time the drug is detected varies on the type of test used. In conclusion:

Urine: Two days for Trazodone and up to 26 days for its metabolites.
Hair can last up to three months.
Three days for blood.
Saliva: From a few hours to four days.

Is there any danger in taking trazodone for sleep? 

Although it is uncommon, trazodone can have major side effects. If you are having any life-threatening symptoms, such as trouble breathing, call 911 or your local emergency services.

Serious concerns, according to the FDA, include:

Suicidal ideation Young adults and children are at a higher risk.
Serotonin syndrome is a condition caused by a lack of serotonin This happens when the body produces too much serotonin, and it can cause dangerous consequences. When using other drugs or supplements that elevate serotonin levels, such as some migraine treatments, the risk of serotonin syndrome increases. Hallucinations, agitation, disorientation, and seizures are some of the symptoms.
increased heart rate, elevated body temperature, and headaches
Tremors, rigidity, and difficulty balancing are all symptoms of muscular tremor.
Vomiting, nausea, and diarrhea
Arrhythmias of the heart If you already have cardiac problems, you are more likely to see changes in heart rhythm.
Priapism. This is a risk of a painful erection lasting a long period.
Hypotension. This abrupt drop in blood pressure may occur more frequently when you rise up from a seated position.
Bleeding risk is increased. Taking blood thinners such as Warfarin, Heparin, or Plavix, which interfere with blood clotting, increases this risk.
Mania. Individuals may feel exhilaration, hyperactivity, or overexcitement.
Vision is hazy.
Hyponatremia. A sodium imbalance in the blood is possible. Headache, disorientation, and weakness are among the symptoms.
Discontinuation syndrome is a condition that occurs when a person stops working. Unlike benzodiazepines, trazodone is not addictive. However, because your body can develop accustomed to trazodone, it is critical to consult with your doctor about the best method to gradually discontinue the medication. Withdrawal symptoms may occur if trazodone is abruptly discontinued.

Trazodone Adverse Effects 

A man sits alone in a green field, contemplating the adverse effects of trazodone on sleep.

If you take trazodone to treat insomnia and then stop taking it, you may have symptoms such as anxiety, irritability, depression, and mild flu-like symptoms. These negative effects can be reduced to a significant extent by gradually weaning off and using less trazodone over time.

Withdrawal effects are quite minor as compared to Ambien.

So, what about more widespread side effects?

It is common to encounter any of the following:

Vision hazard
Walking difficulties or a lack of coordination
Mouth dryness
Blood pressure is low.
Muscle ache
Vomiting or nausea
Heart rate that is really rapid
A rash is one example of a skin reaction.
Weight fluctuations

You may also suffer the following major adverse effects, which are considerably less common:

Heart rhythm irregularities
Symptoms of extrapyramidal nature
The heart attack
Hepatitis is an infection of the liver (liver inflammation)
Hypertension is a medical term that refers to (high blood pressure)
Neutropenia is a condition in which there is a (low white blood cell count)
Orthostatic hypotension is a condition in which the blood pressure rises (low blood pressure when standing)
Priapism is a type of sexual arousal (persistent painful erection)
Exacerbation of psychosis
SIADH is a formalized abbreviation for (Syndrome of Inappropriate Anti-Diuretic Hormone secretion)
Suicidal ideation
Tardive dyskinesia is a type of tardive dyskinesia.
Depression is getting worse.

Trazodone can cause significant responses in rare cases. If you have trouble breathing or have any other serious response, contact 911 right away.

Trazodone, according to the Food and Drug Administration, poses the following significant risks:

Cardiac arrhythmias: These are irregularities in the heart’s rhythm. If you already have heart problems, the danger is increased.
Serotonin syndrome: Excess serotonin in the body can cause unpleasant effects. If you take migraine medication or other supplements, your risk is increased. Dizziness, convulsions, agitation, and hallucinations are some of the symptoms.
Suicidal ideation: There is a risk of suicidal ideation when using trazodone. This is especially common in young adults.
Hypotension is a sudden dip in blood pressure that occurs when you stand up. This is more common in those who take trazodone.
Increased risk of bleeding: If you take blood-thinning medications such as Warfarin or Heparin alongside trazodone, you should be aware that your risk of bleeding increases.
Mania: Trazodone can cause sensations of hyperactivity, exhilaration, and overeagerness.
Priapism: In extremely rare circumstances, trazodone can produce priapism, which is characterized by an erection that lasts a long time and causes pain.

To clarify, if you use trazodone for insomnia, you are extremely unlikely to encounter the majority of the listed negative effects. Nonetheless, you should be informed of everything that could happen.

Overdoes on Trazodone 

There have been cases of trazodone overdoses. These hazards increase when you consume alcohol, use benzodiazepines, or take other central nervous system depressive medicines that decrease your breathing and responses.

Overdoes from drugs can be lethal. If you believe you have taken too much trazodone, call 911 or your local emergency services right away and seek medical care.

Trazodone-Related Dangers

There is limited evidence that trazodone is a habit-forming medicine. However, Trazodone is associated with a number of significant dangers and adverse effects, including:

Overdoes are defined as any dose over 600 mg in less than 24 hours.
Withdrawal: A person who has been taking Trazodone for a long time may build a tolerance to it. When the dosage is reduced, there is a chance of experiencing withdrawal symptoms. Anxiety, agitation, and sleep disturbance are examples of symptoms.
Serotonin Syndrome is a condition in which there is an excess of seroton This is an uncommon yet significant side effect that can occur when the body has too much serotonin.
Trazodone, like any antidepressant, can have serious and unpleasant side effects. While the FDA does not consider it an addictive substance, there is a risk of abuse.

What are the benefits of trazodone for sleeping? 

As the first line of treatment for insomnia and sleep difficulties, experts recommend cognitive behavioral therapy and other behavioral adjustments.

If none of these treatments work for you, your doctor may prescribe trazodone for sleep. If other sleep drugs, such as Xanax, Valium, Ativan, and others (short- to medium-acting benzodiazepine medications), haven’t worked for you, your doctor may prescribe it.

Trazodone has a number of advantages, including:

Insomnia therapy that works. In a 2017 review of research on trazodone use for insomnia, the medicine was found to be helpful in low doses for both primary and secondary insomnia.
Cost savings. Because it is accessible generically, Trazodone is less expensive than other newer insomnia medications.
It is not addicting. Trazodone is not addictive when compared to other drugs, such as those in the benzodiazepine class, such as Valium and Xanax.
May aid in the prevention of age-related mental deterioration. Trazodone may aid in the improvement of slow wave sleep. This may reduce various types of age-related mental deterioration in older adults, such as memory.
If you suffer sleep apnea, this may be a better option. Some sleep medicines have been shown to have a deleterious impact on obstructive sleep apnea and sleep arousal. A tiny 2014 study discovered that 100mg of trazodone improved sleep arousal.



  • This means the medication will most likely stick around in your system for up to the next 40 hours after you’ve taken your dose. (
  • This means that every 5 to 13 hours, the level in your blood will drop by 50 percent. (
  • According to the U.S. National Library of Medicine , when taken in an extended-release oral dose, 70 to 75 percent of trazodone is excreted in urine within 72 hours. (
  • 100% of the fees we collect are used to support our nonprofit mission.
  • Google searches for “insomnia” jumped 58 percent in the months following the pandemic’s onset, according to a February 2021 study in the Journal of Clinical Sleep Medicine . (
  • Around 40 million Americans insomnia every year and about 10 to 15 percent of adults will deal with chronic insomnia.
  • According to a 2008 study Trusted Source , ingesting marijuana strains with higher levels of THC typically reduces the amount of REM sleep you get.
  • Dr. Jordan Tishler , a Harvard-trained physician and cannabis therapeutics specialist, recommends a strain with less than 20 percent THC. (
  • Spring Hill Recovery offers 100% confidential substance abuse assessment and treatment placement tailored to your individual needs. (
  • The majority of these studies (95.5%, 43/45 studies) concluded that trazodone was effective in the treatment of insomnia. (

How Long Does Trazodone Last